Methotrexate induced leucoencephalopathy: A stroke mimic
نویسندگان
چکیده
منابع مشابه
Methotrexate-induced morphological changes mimic those seen after heat shock.
The survival of cells cultured in medium containing the chemotherapeutic drug methotrexate (MTX) is related directly to drug concentration. Changes in DNA resulting from a severe imbalance in the cells' nucleotide pools are thought to account for this cytotoxicity. We have attempted to clarify the gross biochemical changes that might lead to cell death. DNA strand breaks occur in cells treated ...
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متن کاملMethotrexate‐induced leukoencephalopathy presenting as stroke in the emergency department
Methotrexate-induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke-like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be IV or intrathecal and still results in leukoencephalopathy.
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ژورنال
عنوان ژورنال: Annals of Indian Academy of Neurology
سال: 2013
ISSN: 0972-2327
DOI: 10.4103/0972-2327.116922